diff --git a/wp-includes/plugin.php b/wp-includes/plugin.php
index 22ead3632b..4dbab7412a 100644
--- a/wp-includes/plugin.php
+++ b/wp-includes/plugin.php
@@ -840,10 +840,12 @@ function register_uninstall_hook( $file, $callback ) {
 	 * cases. Emphasis should be put on using the 'uninstall.php' way of
 	 * uninstalling the plugin.
 	 */
-	$uninstallable_plugins                             = (array) get_option( 'uninstall_plugins' );
-	$uninstallable_plugins[ plugin_basename( $file ) ] = $callback;
-
-	update_option( 'uninstall_plugins', $uninstallable_plugins );
+	$uninstallable_plugins = (array) get_option( 'uninstall_plugins' );
+	$plugin_basename       = plugin_basename( $file );
+	if ( ! isset( $uninstallable_plugins[ $plugin_basename ] ) || $uninstallable_plugins[ $plugin_basename ] !== $callback ) {
+		$uninstallable_plugins[ $plugin_basename ] = $callback;
+		update_option( 'uninstall_plugins', $uninstallable_plugins );
+	}
 }
 
 /**
diff --git a/wp-includes/version.php b/wp-includes/version.php
index d495481bf5..552e24e91e 100644
--- a/wp-includes/version.php
+++ b/wp-includes/version.php
@@ -13,7 +13,7 @@
  *
  * @global string $wp_version
  */
-$wp_version = '5.3-beta1-46332';
+$wp_version = '5.3-beta1-46333';
 
 /**
  * Holds the WordPress DB revision, increments when changes are made to the WordPress DB schema.