diff --git a/wp-includes/class-wp-theme-json.php b/wp-includes/class-wp-theme-json.php
index d01ce6e8b2..311705b9ad 100644
--- a/wp-includes/class-wp-theme-json.php
+++ b/wp-includes/class-wp-theme-json.php
@@ -2900,10 +2900,10 @@ class WP_Theme_JSON {
 			$css .= '.has-global-padding { padding-right: var(--wp--style--root--padding-right); padding-left: var(--wp--style--root--padding-left); }';
 			// Alignfull children of the container with left and right padding have negative margins so they can still be full width.
 			$css .= '.has-global-padding > .alignfull { margin-right: calc(var(--wp--style--root--padding-right) * -1); margin-left: calc(var(--wp--style--root--padding-left) * -1); }';
-			// Nested children of the container with left and right padding that are not wide or full aligned do not get padding.
-			$css .= '.has-global-padding :where(.has-global-padding:not(.wp-block-block, .alignfull, .alignwide)) { padding-right: 0; padding-left: 0; }';
-			// Nested children of the container with left and right padding that are not wide or full aligned do not get negative margin applied.
-			$css .= '.has-global-padding :where(.has-global-padding:not(.wp-block-block, .alignfull, .alignwide)) > .alignfull { margin-left: 0; margin-right: 0; }';
+			// Nested children of the container with left and right padding that are not wide or full aligned do not get padding, unless they are direct children of an alignfull flow container.
+			$css .= '.has-global-padding :where(:not(.alignfull.is-layout-flow) > .has-global-padding:not(.wp-block-block, .alignfull, .alignwide)) { padding-right: 0; padding-left: 0; }';
+			// Alignfull direct children of the containers that are targeted by the rule above do not need negative margins.
+			$css .= '.has-global-padding :where(:not(.alignfull.is-layout-flow) > .has-global-padding:not(.wp-block-block, .alignfull, .alignwide)) > .alignfull { margin-left: 0; margin-right: 0; }';
 		}
 
 		$css .= '.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }';
diff --git a/wp-includes/version.php b/wp-includes/version.php
index 593ff9a884..d5c8ce5e06 100644
--- a/wp-includes/version.php
+++ b/wp-includes/version.php
@@ -16,7 +16,7 @@
  *
  * @global string $wp_version
  */
-$wp_version = '6.6-beta3-58443';
+$wp_version = '6.6-beta3-58444';
 
 /**
  * Holds the WordPress DB revision, increments when changes are made to the WordPress DB schema.